Sunday, February 27, 2022
10:30 a.m. – 12:00 p.m.
On Zoom
Abstract
The Vibrational Imaging Laboratory at KAUST focuses on the development of new photonics-based tools for the biomedical field. In particular, we aim to develop a new generation of label-free microscopy systems and multi-function optical probes for biologists and clinicians. To this end, our research program entails two complementary research themes.
The first research line leverages the potential of 3D micro-printing to develop novel micro-optic devices for bio-photonic applications. This cutting-edge technology provides unprecedented three-dimensional micro-fabrication capabilities and aligns with the increasing demand for the miniaturization of optical probes and setups towards compact, portable, less-invasive and point-of-care smart devices. Within this research line, my group has demonstrated new concepts on how to control the light output from optical fibers, often enabling previously unattainable on-fiber functionalities for the first time.
The second research line aims to develop label-free optical microscopy based on vibrational spectroscopy and explore its biomedical applications. The use of the vibrational spectra of biomolecules as a source of contrast is poised to generate a next-generation bioimaging platform, providing a new dimension to the traditional imaging methods used in biomedical research and clinical activity. In particular, we have introduced a novel architecture for stimulated Raman scattering (SRS) microscopy that uniquely allows a seamless automated operation across the whole relevant molecular vibrational spectrum, and more advanced SRS acquisition modalities without any modification of the optical setup.Our approach strongly connects method development with real-world applications in order to deliver solutions that are well focused on addressing real challenges and providing new possibilities. In this talk, I will summarize the most significant accomplishments of my laboratory and outline my future research plans.
About the speaker
Carlo Liberale is Assistant Professor of Bioscience, Electrical and Computer Engineering, and Bioengineering at KAUST, where he’s heading the Vibrational Imaging (VIBRA) Lab. He received his Ph.D. in Electrical Engineering from the University of Pavia (Italy).
His research group focuses on developing and applying label-free chemical microscopy techniques based on vibrational spectroscopy.
Additionally, his lab uses high-resolution 3D printing based on two-photon lithography to miniaturize complex optical systems. Using this approach, he has pioneered the fabrication of novel micro-optical components directly integrated at the end-face of optical fibers. This research activity takes advantage of an integrated approach that combines design, micro/nanofabrication, and optical techniques.
He has authored more than 70 publications and eight patent applications. He is a Senior Member of the Institute of Electrical and Electronics Engineers (IEEE) and the Optical Society of America (OSA).